BioWeaver
Tools for cross-species genomic data.
Tools
Complementation ExplorerFollow an experiment →Explore SGD's directed functional complementation records. Keep experimental notes, curation sources and publications beside each gene relationship.
OrthoDB Group ExplorerExplore gene families →Explore a prepared collection of gene families at different taxonomic depths. Inspect group membership while keeping species, assemblies and multiple copies distinct.
PANTHER Tree ExplorerExplore family trees →Open clades and find genes in selected PANTHER families, including TP53, BRCA1, BRAF and PTEN. Inspect source annotations, switch branch spacing and download the original tree or your current figure.
7 families3,229 tips181 tips resolved to indexed genes
Drug Evidence ExplorerExplore compounds →Inspect compound activity and mechanism records for a cohort of human anchor genes and their indexed orthologs. Keep assays, variants, source records and measured species together.
8 anchor genes13 ChEMBL targets975 activity rows
Anchor genes: BRAF, EGFR, PCSK9, TP53, BRCA1, PTEN, ARAF, RAF1. Source: ChEMBL 37, CC BY-SA 3.0. Activity is not transferred across orthology.
Fungal Mapping ExplorerExplore fungal mappings →Follow PomBase's curated gene mappings and inspect CGD group membership across fungal species and strains. Keep source identifiers and unresolved records visible.
5,667 PomBase human mappings5,353 PomBase budding-yeast mappings16,716 CGOB groups
Graph ExplorerExplore connected evidence →Build a network from your gene list, expand ortholog candidates, and inspect the records behind disease associations. Save portable graphs for the browser or Python.
Loom Open Loom →Genes, orthologs and diseases across the model species Loom indexes. Search a symbol, follow it to its orthologs, and see which diseases it is associated with and on what evidence.
Evidence Map Open Evidence Map →For every disease, which model species has a gene association someone actually curated, and which merely inherited one from a human curation through orthology.
63,720 disease-species cells80% hold an association18.4% are curated
Unresolved Open Unresolved →For genes people actually test, how much of what has been found is still classified uncertain. Genes strongly intolerant of loss of function still return variants nobody can classify. ClinVar and gnomAD only.
15,447 tested genes1,269 genes with LOEUF below 0.35
Unseen Open Unseen →Swiss-Prot curators have reviewed the human proteome and recorded nothing about some of its proteins: no protein-level evidence, no function or no Gene Ontology term. UniProt and gnomAD only.
20,431 reviewed human proteins1,765 never observed as a protein3,090 with no function1,056 with no GO term
Evidence auditAudit a list →Inspect a human gene list across constraint, clinical variant counts, proteins, disease annotations and mouse models. Keep missing states and source provenance visible.
44,649 indexed human genes
Orthology workbenchMap a list →Translate lists across species using Alliance stringent orthology. Compare supporting methods, preserve alternatives and export explicit mapping decisions.
911,078 stringent ortholog edges46 species pairs
Evidence TrailTrace evidence →Follow disease annotations to their explicitly named source genes, evidence codes and references. Inspect inferred, curated and negative records separately.
424,482 disease annotations55,640 curated367,629 inferred from an ortholog1,213 negative
Cross-species ComparatorCompare genes →Read ortholog candidates side by side: disease, GO and phenotype evidence, with gnomAD constraint, NCBI human metadata and FlyBase complementation context.
Source ages
30 of 39 sources carry a release or retrieval date; 9 have none usable. Each bar counts days from the oldest date any tool records for that source to the build date, 2026-11-03. A release date is used when recorded, otherwise the retrieval date.
Solid: days since release. Outlined: days since retrieval. Hatched: no usable date.