BioWeaver

Genes, orthologs and diseases across nine model species. Search a symbol, follow it to its orthologs, and see which diseases it is associated with and on what evidence.

For every disease, which model species has a gene association someone actually curated — and which merely inherited one from a human curation through orthology. The grid looks 84% full; 17.6% of it is curated.

For genes people actually test, how much of what has been found is still classified uncertain. 1,261 genes are strongly intolerant of loss of function and still returning variants nobody can classify. ClinVar and gnomAD only.

Swiss-Prot curators have reviewed 20,431 human proteins and recorded nothing about some of them. 1,765 have never been observed as a protein, 3,090 carry no function and 1,056 carry no Gene Ontology term at all. UniProt and gnomAD only.